Synthesis of β-estradiol-3-benzoate-17-(succinyl-12A-tetracycline): A potential bone-seeking estrogen

The title compound, designed as a bone-seeking estrogen prodrug, was synthesized, characterized and shown to bind to hydroxylapatite, the mineral constituent of bone tissue. The title compound, designed as a bone-seeking estrogen prodrug, was synthesized, characterized and shown to bind to hydroxyla...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 4; no. 11; pp. 1375 - 1380
Main Authors Orme, Mark W., Labroo, Virender M.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 09.06.1994
Elsevier
Subjects
Alicyclic compounds, terpenoids, prostaglandins, steroids
Chemistry
Exact sciences and technology
Organic chemistry
Preparations and properties
Steroids
Steroid
Ketol
Enol
Estrogen
Tetracyclic compound
Prodrug
Target
Ammonium compound
Targeted drug
Phenols
Carboxamide
Aromatic compound
Bone
Acylate
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Summary:The title compound, designed as a bone-seeking estrogen prodrug, was synthesized, characterized and shown to bind to hydroxylapatite, the mineral constituent of bone tissue. The title compound, designed as a bone-seeking estrogen prodrug, was synthesized, characterized and shown to bind to hydroxylapatite, the mineral constituent of bone tissue.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80365-6