Benzylic C(sp 3 )-H fluorination

The selective fluorination of C(sp )-H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent years much attention has been focused on C(sp )-H fluorination, and several methods that are selective for benzylic C-H bonds have been repor...

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Published inBeilstein journal of organic chemistry Vol. 20; no. 1; pp. 1527 - 1547
Main Authors Atkins, Alexander P, Dean, Alice C, Lennox, Alastair J J
Format Journal Article
LanguageEnglish
Published Germany Beilstein-Institut 10.07.2024
Subjects
benzylic
Chemistry
c–h functionalization
fluorination
photoredox catalysis
Review
fluorination
benzylic
photoredox catalysis
C–H functionalization
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Abstract The selective fluorination of C(sp )-H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent years much attention has been focused on C(sp )-H fluorination, and several methods that are selective for benzylic C-H bonds have been reported. These protocols operate via several distinct mechanistic pathways and involve a variety of fluorine sources with distinct reactivity profiles. This review aims to give context to these transformations and strategies, highlighting the different tactics to achieve fluorination of benzylic C-H bonds.
AbstractList The selective fluorination of C(sp 3 )–H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent years much attention has been focused on C(sp 3 )–H fluorination, and several methods that are selective for benzylic C–H bonds have been reported. These protocols operate via several distinct mechanistic pathways and involve a variety of fluorine sources with distinct reactivity profiles. This review aims to give context to these transformations and strategies, highlighting the different tactics to achieve fluorination of benzylic C–H bonds.
The selective fluorination of C(sp 3 )–H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent years much attention has been focused on C(sp 3 )–H fluorination, and several methods that are selective for benzylic C–H bonds have been reported. These protocols operate via several distinct mechanistic pathways and involve a variety of fluorine sources with distinct reactivity profiles. This review aims to give context to these transformations and strategies, highlighting the different tactics to achieve fluorination of benzylic C–H bonds.
The selective fluorination of C(sp3)-H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent years much attention has been focused on C(sp3)-H fluorination, and several methods that are selective for benzylic C-H bonds have been reported. These protocols operate via several distinct mechanistic pathways and involve a variety of fluorine sources with distinct reactivity profiles. This review aims to give context to these transformations and strategies, highlighting the different tactics to achieve fluorination of benzylic C-H bonds.The selective fluorination of C(sp3)-H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent years much attention has been focused on C(sp3)-H fluorination, and several methods that are selective for benzylic C-H bonds have been reported. These protocols operate via several distinct mechanistic pathways and involve a variety of fluorine sources with distinct reactivity profiles. This review aims to give context to these transformations and strategies, highlighting the different tactics to achieve fluorination of benzylic C-H bonds.
The selective fluorination of C(sp3)–H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent years much attention has been focused on C(sp3)–H fluorination, and several methods that are selective for benzylic C–H bonds have been reported. These protocols operate via several distinct mechanistic pathways and involve a variety of fluorine sources with distinct reactivity profiles. This review aims to give context to these transformations and strategies, highlighting the different tactics to achieve fluorination of benzylic C–H bonds.
The selective fluorination of C(sp )-H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent years much attention has been focused on C(sp )-H fluorination, and several methods that are selective for benzylic C-H bonds have been reported. These protocols operate via several distinct mechanistic pathways and involve a variety of fluorine sources with distinct reactivity profiles. This review aims to give context to these transformations and strategies, highlighting the different tactics to achieve fluorination of benzylic C-H bonds.
Author Lennox, Alastair J J
Dean, Alice C
Atkins, Alexander P
AuthorAffiliation 1 University of Bristol, School of Chemistry, Bristol, BS8 1TS, U.K. https://ror.org/0524sp257 https://www.isni.org/isni/0000000419367603
AuthorAffiliation_xml – name: 1 University of Bristol, School of Chemistry, Bristol, BS8 1TS, U.K. https://ror.org/0524sp257 https://www.isni.org/isni/0000000419367603
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  surname: Lennox
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Issue 1
Keywords fluorination
benzylic
photoredox catalysis
C–H functionalization
Language English
License Copyright © 2024, Atkins et al.
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Snippet The selective fluorination of C(sp )-H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent...
The selective fluorination of C(sp 3 )–H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over...
The selective fluorination of C(sp3)-H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent...
The selective fluorination of C(sp 3 )–H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over...
The selective fluorination of C(sp3)–H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent...
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StartPage 1527
SubjectTerms benzylic
Chemistry
c–h functionalization
fluorination
photoredox catalysis
Review
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Title Benzylic C(sp 3 )-H fluorination
URI https://www.ncbi.nlm.nih.gov/pubmed/39015617
https://www.proquest.com/docview/3081777113/abstract/
https://pubmed.ncbi.nlm.nih.gov/PMC11250007
https://doaj.org/article/e1e1e6db9a184e70b921d8039b265005
Volume 20
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