Benzylic C(sp 3 )-H fluorination

The selective fluorination of C(sp )-H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent years much attention has been focused on C(sp )-H fluorination, and several methods that are selective for benzylic C-H bonds have been repor...

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Published inBeilstein journal of organic chemistry Vol. 20; no. 1; pp. 1527 - 1547
Main Authors Atkins, Alexander P, Dean, Alice C, Lennox, Alastair J J
Format Journal Article
LanguageEnglish
Published Germany Beilstein-Institut 10.07.2024
Subjects
benzylic
Chemistry
c–h functionalization
fluorination
photoredox catalysis
Review
fluorination
benzylic
photoredox catalysis
C–H functionalization
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Summary:The selective fluorination of C(sp )-H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent years much attention has been focused on C(sp )-H fluorination, and several methods that are selective for benzylic C-H bonds have been reported. These protocols operate via several distinct mechanistic pathways and involve a variety of fluorine sources with distinct reactivity profiles. This review aims to give context to these transformations and strategies, highlighting the different tactics to achieve fluorination of benzylic C-H bonds.
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ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.20.137