Intramuscular butorphanol and meperidine in postoperative pain

Butorphanol, 1, 2, and 4 mg/70 kg, and meperidine, 40 and 80 mg/70 kg, were compared for analgesic activity and side effects in 104 hospitalized postoperative patients. Butorphanol proved to be 30 to 40 times as potent as meperidine on a weight basis. Both medications provided maximum pain relief ap...

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Bibliographic Details
Published inClinical pharmacology and therapeutics Vol. 20; no. 3; p. 359
Main Authors Gilbert, M S, Hanover, R M, Moylan, D S, Caruso, F S
Format Journal Article
LanguageEnglish
Published United States 01.09.1976
Subjects
Adult
Aged
Analgesics - administration & dosage
Analgesics - adverse effects
Analgesics - therapeutic use
Clinical Trials as Topic
Female
Humans
Injections, Intramuscular
Male
Meperidine - administration & dosage
Meperidine - adverse effects
Meperidine - therapeutic use
Middle Aged
Morphinans - administration & dosage
Morphinans - adverse effects
Morphinans - therapeutic use
Pain, Postoperative - drug therapy
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Summary:Butorphanol, 1, 2, and 4 mg/70 kg, and meperidine, 40 and 80 mg/70 kg, were compared for analgesic activity and side effects in 104 hospitalized postoperative patients. Butorphanol proved to be 30 to 40 times as potent as meperidine on a weight basis. Both medications provided maximum pain relief approximately 1 hr after administration. The most common side effect in all groups was drowsiness.
ISSN:0009-9236
DOI:10.1002/cpt1976203359