Carbamazepine blocks NMDA-activated currents in cultured spinal cord neurons

The antiepileptic agents, carbamazepine and phenytoin, suppress seizures in man and convulsant-induced hyperactivity in spinal cord nerve cell cultures. In the present study, we have shown by whole cell recording that carbamazepine, in contrast to phenytoin, blocks N-methyl-D-aspartate (NMDA)-activa...

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Bibliographic Details
Published inNeuroreport Vol. 1; no. 1; p. 26
Main Authors Lampe, H, Bigalke, H
Format Journal Article
LanguageEnglish
Published England 01.09.1990
Subjects
2-Amino-5-phosphonovalerate - analogs & derivatives
Amino Acids - pharmacology
Animals
Carbamazepine - pharmacology
Cells, Cultured
Dizocilpine Maleate - pharmacology
Electrophysiology
Female
Ion Channels - drug effects
Membrane Potentials - drug effects
Mice
N-Methylaspartate - antagonists & inhibitors
N-Methylaspartate - physiology
Neurons - drug effects
Neurons - metabolism
Phenytoin - pharmacology
Pregnancy
Spinal Cord - cytology
Spinal Cord - physiology
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Summary:The antiepileptic agents, carbamazepine and phenytoin, suppress seizures in man and convulsant-induced hyperactivity in spinal cord nerve cell cultures. In the present study, we have shown by whole cell recording that carbamazepine, in contrast to phenytoin, blocks N-methyl-D-aspartate (NMDA)-activated membrane currents in cultured neurons in a dose-dependent fashion. The NMDA receptor-activated channel, which is blocked at physiological concentrations of Mg2+ at resting membrane potential, can be activated by glutamate in depolarized neurons and thus be involved in epileptogenesis. Therefore, the block of NMDA-evoked membrane currents in cultured neurons may contribute to the clinical effectiveness of carbamazepine.
ISSN:0959-4965
DOI:10.1097/00001756-199009000-00008