Post-Traumatic Trigeminal Neuropathic Pain: A Narrative Review of Understanding, Management, and Prognosis

• Published in: Biomedicines Vol. 12; no. 9; p. 2058
• Main Authors: Park, Hyun-Jeong, Ahn, Jong-Mo, Ryu, Ji-Won
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.09.2024; MDPI
• Subjects: Age composition; Chronic illnesses; Chronic pain; Development and progression; Evidence-based medicine; Homeopathy; Hyperalgesia; Injuries; Management; Materia medica and therapeutics; Maxillofacial; Nervous system; Neuralgia; neuropathic pain; Neurophysiology; Pathophysiology; Patients; post-trauma; Prognosis; Quality of life; Review; Sensory properties; Stress; Therapeutics; Trauma; Trigeminal nerve; Tumor necrosis factor-TNF; post-trauma; trigeminal nerve; neuropathic pain; management
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines12092058

This study provides an updated overview of the clinical characteristics of post-traumatic trigeminal neuropathic pain (PTNP) resulting from dental procedures or facial trauma, addressing its etiology, prevalence, evaluation, management, and prognosis. PTNP arises from injury to the trigeminal nerve, which governs sensory and motor functions in the maxillofacial region. The prevalence and characteristics of PTNP vary considerably across studies, with a reported prevalence ranging from 1.55% to 13%. The predominant causative factors are dental procedures, particularly third molar removal and implant placement. While gender distribution varies, a trend towards higher incidence in females is observed, particularly within the 40-60-year age group. Anatomically, the mandibular nerve is frequently involved. PTNP presents with a spectrum of symptoms ranging from tingling sensations to severe pain. Diagnostic challenges arise due to the lack of standardized criteria and potential overlap with focal neuralgia, necessitating comprehensive evaluation. Misdiagnosis can lead to prolonged patient suffering and unnecessary interventions. Successful management hinges on prompt diagnosis and interdisciplinary collaboration, with early intervention crucial in mitigating progression to chronic pain. Although nerve recovery post-trauma is challenging, preventive measures through accurate evaluation and treatment are paramount. Management strategies for PTNP include non-invasive and surgical interventions, with non-invasive approaches encompassing systemic and local pharmacological management. This narrative review aims to enhance uniformity in PTNP evaluation and treatment approaches, ultimately improving patient care and outcomes.