Induction and effector functions of TH17 cells

T helper (T H ) cells constitute an important arm of the adaptive immune system because they coordinate defence against specific pathogens, and their unique cytokines and effector functions mediate different types of tissue inflammation. The recently discovered T H 17 cells, the third subset of effe...

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Bibliographic Details
Published inNature (London) Vol. 453; no. 7198; pp. 1051 - 1057
Main Authors BETTELLI, Estelle, KORN, Thomas, OUKKA, Mohamed, KUCHROO, Vijay K
Format Journal Article
LanguageEnglish
Published London Nature Publishing 19.06.2008
Subjects
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genetics of the immune response
Immunobiology
Autoimmunity
TH17 lymphocyte
Acquired immunity
Induction
Immune tolerance
Inflammation
Review
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Summary:T helper (T H ) cells constitute an important arm of the adaptive immune system because they coordinate defence against specific pathogens, and their unique cytokines and effector functions mediate different types of tissue inflammation. The recently discovered T H 17 cells, the third subset of effector T helper cells, have been the subject of intense research aimed at understanding their role in immunity and disease. Here we review emerging data suggesting that T H 17 cells have an important role in host defence against specific pathogens and are potent inducers of autoimmunity and tissue inflammation. In addition, the differentiation factors responsible for their generation have revealed an interesting reciprocal relationship with regulatory T (T reg ) cells, which prevent tissue inflammation and mediate self-tolerance.
Bibliography:Present address: Neurologische Klinik, Klinikum rechts der Isar, Technische Universität Munich, Germany.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature07036