Bumetanide, a new loop diuretic

The effect of bumetanide on renal function has been compared with that of furosemide and a placebo in a double-blind study of 9 healthy young men. The sequence for oral administration of the drug was subjected to a random assignation based upon the Latin-square methodology under three different cond...

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Bibliographic Details
Published inClinical pharmacology and therapeutics Vol. 20; no. 4; p. 424
Main Authors Carrière, S, Dandavino, R
Format Journal Article
LanguageEnglish
Published United States 01.10.1976
Subjects
Adult
Blood Pressure - drug effects
Bumetanide - pharmacology
Clinical Trials as Topic
Dehydration
Diuretics - pharmacology
Furosemide - pharmacology
Humans
Male
Placebos
Time Factors
Water - pharmacology
Water Deprivation
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Summary:The effect of bumetanide on renal function has been compared with that of furosemide and a placebo in a double-blind study of 9 healthy young men. The sequence for oral administration of the drug was subjected to a random assignation based upon the Latin-square methodology under three different conditions. (1) Normal hydration: The administration of bumetanide (2 mg) produced within the next 4 hr a diuresis comparable to that induced by 80 mg of furosemide. Urinary excretion of sodium, potassium, chloride, calcium, and uric acid also followed comparable patterns. Phosphaturia occurred only under bumetanide. The effect of bumetanide seemed longer lasting. (2) Water loading: The effects of bumetanide and furosemide were comparable with the exception of the phosphaturic effect induced by bumetanide. The action of both diuretics on the diluting segment of the nephron was well demonstrated by the marked depression of CH2O. (3) Water deprivation: The effects of the two diuretics were comparable, including depression tCH20. In none of these conditions did the placebo produce any significant effect.
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt1976204424