Synthesis and antibacterial activity of novel series of 2-(p-tolyloxy)-3-(5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)quinoline

A new series of 2‐(p‐tolyloxy)‐3‐(5‐(pyridin‐4‐yl)‐1,3,4‐oxadiazol‐2‐yl)quinoline were synthesized from oxidative cyclization of N′‐((2‐(p‐tolyloxy)quinoline‐3‐yl)methylene)isonicotinohydrazide in DMSO/I2 at reflux condition for 3–4 h. The structures of the new compounds were confirmed by elemental...

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Published inJournal of heterocyclic chemistry Vol. 48; no. 4; pp. 872 - 876
Main Authors Joshi, Ratnadeep S., Mandhane, Priyanka G., Khan, Wajid, Gill, Charansingh H.
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.07.2011
Wiley
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
OXIDATION
KETONES
N-ACYLHYDRAZONES
FACILE SYNTHESIS
ONE-POT SYNTHESIS
ACIDS
ALDEHYDES
AGENTS
1,3,4-OXADIAZOLES
QUINOLINE ALKALOIDS
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Summary:A new series of 2‐(p‐tolyloxy)‐3‐(5‐(pyridin‐4‐yl)‐1,3,4‐oxadiazol‐2‐yl)quinoline were synthesized from oxidative cyclization of N′‐((2‐(p‐tolyloxy)quinoline‐3‐yl)methylene)isonicotinohydrazide in DMSO/I2 at reflux condition for 3–4 h. The structures of the new compounds were confirmed by elemental analyses as well as IR, 1H‐NMR, and mass spectral data. All the synthesized compounds were screened for their antibacterial activities against various bacterial strains. Several of these compounds showed potential antibacterial activity. J. Heterocyclic Chem., (2011).
Bibliography:istex:558C86A69E47876521A50DF64DA38A0B79AEAC6E
ArticleID:JHET653
ark:/67375/WNG-CTK9BS8D-X
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.653