Respiratory syncytial virus： the possible trigger of airway remodeling through matrix metalloproteinase activation

• Published in: Chinese medical journal Vol. 120; no. 1; pp. 3 - 4
• Main Authors: Wen, Fu-Qiang, Liu, Dai-Shun
• Format: Journal Article
• Language: English
• Published: China Department of Respiratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu 610041,China 05.01.2007
• Subjects: Allergens - immunology; Animals; Asthma - etiology; Enzyme Activation; Lung - pathology; Matrix Metalloproteinases - physiology; Mice; Respiratory Syncytial Virus Infections - enzymology; Respiratory Syncytial Virus Infections - pathology; 呼吸道合胞病毒; 支气管肺炎; 毛细支气管炎; 组织培养; matrix metalloproteinase; respiratory syncytial virus; airway remodeling
• ISSN: 0366-6999; 2542-5641
• DOI: 10.1097/00029330-200701010-00001

Respiratory syncytial virus （RSV） is a leading cause of .epidemic respiratory tract illness in children. Severe RSV infections involving the lower respiratory tract are primarily seen in young children with naive immune systems and/or genetic predispositions. However, RSV was not recognized as a potentially serious problem in older adults until the 1970s, when outbreaks of the virus infection occurred in long-term care facilities. Since then, additional studies in hospitalized adults have suggested that RSV may be an important cause of illness in community-dwelling elderly people, patients with suppressed T-cell immunity （such as heart transplant recipients）.