Marine algae that display anti-tumorigenic activity against Agrobacterium tumefaciens

• Published in: FEMS microbiology letters Vol. 128; no. 2; pp. 151 - 156
• Main Authors: El-Masry, M.H, Mostafa, M.H, Ibrahim, A.M, El-Naggar, M.M.A
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.1995; Blackwell
• Subjects: Agrobacterium tumefaciens; Agrobacterium tumefaciens - drug effects; algae and seaweeds; algal extracts; antibacterial properties; antineoplastic agents; Antineoplastic Agents - pharmacology; Anti‐tumor agent; Bacterial plant pathogens; Biological and medical sciences; biological control; Codium tomentosum; Crown gall; crown galls; Drug Screening Assays, Antitumor; Eukaryota - chemistry; Fundamental and applied biological sciences. Psychology; Generalities. Techniques. Transmission, epidemiology, ecology. Antibacterial substances, control; in vitro; Jania rubens; Marine; Marine alga; Padina pavonica; Phytopathology. Animal pests. Plant and forest protection; plant extracts; Plant Extracts - pharmacology; Plant Tumors - microbiology; Seawater; Solanum tuberosum; MED, Egypt, Arab Rep., Alexandria; Antineoplastic agent; Crown gall; Plant pathogen; Algae; Biological control; Chlorophycophyta; Marine plant; Agrobacterium tumefaciens; In vitro; Phaeophycophyta; Rhodophycophyta; Infection; Bacteriosis; Bacteria; Rhizobiaceae; Antibacterial agent; Thallophyta
• ISSN: 0378-1097; 1574-6968
• DOI: 10.1111/j.1574-6968.1995.tb07515.x

Thirty-five extracts representing different seasonal growths of 17 marine algal species collected from the Alexandria coast were tested for anti-tumorigenic activity against Agrobacterium tumefaciens galls on potato discs. Eleven extracts (nine species) displayed > 20% inhibition of tumor initiation, with three of these (Codium tomentosum, winter; Jania rubens, summer; Padina pavonia, winter) displaying relatively high activity. Bacterial viability tests showed that the inhibitory effects were directly due to anti-tumorigenesis rather than an indirect result of anti-bacterial activity.