Core-Needle Biopsy Efficacy in Histopathology Diagnosis of Canine Multicentric Lymphoma

Core-needle biopsy (CNB) is now widely used to diagnose and classify human lymphoma. Few studies, however, have reported the use of CNB in veterinary medicine for dogs with suspected lymphoma. The present study evaluated the efficacy of CNB sample collection to diagnose canine multicentric lymphoma...

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Published inTopics in companion animal medicine Vol. 45; p. 100561
Main Authors Silva do Nascimento, Juliana, Maués, Tábata, da Silva Leite, Juliana, Reis Ferreira, Ana Maria, Gonçalves Ferreira, Maria de Lourdes
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2021
Elsevier Limited
Subjects
Animals
Biopsy
Biopsy, Needle - veterinary
Blood tests
Bone marrow
Cell size
Diagnosis
Diagnosis, Differential
Differential diagnosis
dog
Dog Diseases - diagnosis
Dogs
Evaluation
excisional biopsy
Histopathology
Lymph nodes
lymphadenectomy
Lymphadenopathy
Lymphatic system
lymphocyte
Lymphocytes
Lymphoma
Lymphoma - diagnosis
Lymphoma - veterinary
Medical diagnosis
morphotype
Tumors
Veterinary medicine
morphotype
dog
excisional biopsy
lymphadenectomy
lymphocyte
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Summary:Core-needle biopsy (CNB) is now widely used to diagnose and classify human lymphoma. Few studies, however, have reported the use of CNB in veterinary medicine for dogs with suspected lymphoma. The present study evaluated the efficacy of CNB sample collection to diagnose canine multicentric lymphoma morphology. 16 dogs of varying breeds with generalized peripheral lymphadenopathy and cytopathologic features suggestive of lymphoma were enrolled in the study. CNB followed by lymphadenectomy of the left popliteal lymph node was performed. Both samples underwent histopathologic evaluation. Among the 16 dogs, 14 had lymphoma. CNB was positive for lymphoma in 12 (85.7%) of these 14 dogs. CNB analysis for diagnosing dogs with multicentric lymphoma exhibited a sensitivity of 86% and a specificity of 100%. CNB was effective in generalized lymphadenopathies toward achieving a differential diagnosis and microscopic evaluation of multicentric lymphoma in dogs, revealing essential features for morphologic classification, such as cell size, histopathologic type, and grade.
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ISSN:1938-9736
1946-9837
1876-7613
DOI:10.1016/j.tcam.2021.100561