Carbohydrate recognition by Mycoplasma pneumoniae and pathologic consequences

Mycoplasma pneumoniae infection in the human is often followed by a transient autoimmune hemolytic disorder characterized by high titer autoantibodies to a carbohydrate antigen, the I antigen. Because the major host cell receptor for the Mycoplasma is the sialylated form of this antigen, it is likel...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 154; no. 4 Pt 2; p. S133
Main Authors Feizi, T, Loveless, R W
Format Journal Article
LanguageEnglish
Published United States 01.10.1996
Subjects
Antigens, Surface - immunology
Autoantibodies - biosynthesis
Blood Group Antigens
Carbohydrates - immunology
Humans
I Blood-Group System - immunology
Membrane Glycoproteins - immunology
Mycoplasma pneumoniae - immunology
Oligosaccharides - immunology
Pneumonia, Mycoplasma - immunology
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Summary:Mycoplasma pneumoniae infection in the human is often followed by a transient autoimmune hemolytic disorder characterized by high titer autoantibodies to a carbohydrate antigen, the I antigen. Because the major host cell receptor for the Mycoplasma is the sialylated form of this antigen, it is likely that the immunologic disorder is initiated by the microbe-saccharide interaction. Here we review briefly knowledge on the autoantibodies and the structures and distribution of the saccharide antigens and receptors. We discuss possible mechanisms for the triggering of autoantibody production and consider ways in which perturbation of various glycoprotein carriers of the carbohydrate ligands may elicit a variety of pathobiologic responses. We conclude by highlighting ideas on further molecular dissections of the elements of the microbe-host interaction.
ISSN:1073-449X
DOI:10.1164/ajrccm/154.4_Pt_2.S133