Single-pixel transmission matrix recovery via two-photon fluorescence

Imaging at depth in opaque materials has long been a challenge. Recently, wavefront shaping has enabled notable advance for deep imaging. Nevertheless, most noninvasive wavefront-shaping methods require cameras, lack the sensitivity for deep imaging under weak optical signals, or can only focus on a...

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Published inScience advances Vol. 10; no. 3; p. eadi3442
Main Authors Zhao, Shupeng, Rauer, Bernhard, Valzania, Lorenzo, Dong, Jonathan, Liu, Ruifeng, Li, Fuli, Gigan, Sylvain, de Aguiar, Hilton B
Format Journal Article
LanguageEnglish
Published United States 19.01.2024
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Summary:Imaging at depth in opaque materials has long been a challenge. Recently, wavefront shaping has enabled notable advance for deep imaging. Nevertheless, most noninvasive wavefront-shaping methods require cameras, lack the sensitivity for deep imaging under weak optical signals, or can only focus on a single "guidestar." Here, we retrieve the transmission matrix (TM) noninvasively using two-photon fluorescence exploiting a single-pixel detection combined with a computational framework, allowing to achieve single-target focus on multiple guidestars spread beyond the memory effect range. In addition, if we assume that memory effect correlations exist in the TM, we are able to substantially reduce the number of measurements needed.
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ISSN:2375-2548
2375-2548
DOI:10.1126/sciadv.adi3442