Co-delivery of enzymes and photosensitizers via metal-phenolic network capsules for enhanced photodynamic therapy

• Published in: Chinese chemical letters Vol. 33; no. 4; pp. 1917 - 1922
• Main Authors: Wang, Qian, Gao, Zhiliang, Zhao, Kaijie, Zhang, Peiyu, Zhong, Qi-Zhi, Yu, Qun, Zhai, Shumei, Cui, Jiwei
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.04.2022; Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education,School of Chemistry and Chemical Engineering,Shandong University,Ji'nan 250100,China%Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education,School of Chemistry and Chemical Engineering,Shandong University,Ji'nan 250100,China; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology,and the Department of Chemical Engineering,The University of Melbourne,Parkville,VIC 3010,United States%Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education,School of Chemistry and Chemical Engineering,Shandong University,Ji'nan 250100,China; State Key Laboratory of Microbial Technology,Shandong University,Qingdao 266237,China
• Subjects: Capsule; Drug delivery; Metal-phenolic network (MPN); Oxygen self-supply; Photodynamic therapy (PDT); Oxygen self-supply; Metal-phenolic network (MPN); Capsule; Drug delivery; Photodynamic therapy (PDT); Metal-phenolic network(MPN); Photodynamic therapy(PDT)
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2021.11.040

The intrinsic hypoxic tumor microenvironment and limited accumulation of photosensitizers (PSs) result in unsatisfied efficiency of photodynamic therapy (PDT). To enhance the PDT efficiency against solid tumors, a functional oxygen self-supplying and PS-delivering nanosystem is fabricated via the combination of catalase (CAT), chlorin e6 (Ce6) and metal-phenolic network (MPN) capsule. It is demonstrated that the CAT encapsulated in the capsules (named CCM capsules) could catalyze the degradation of hydrogen peroxide (H2O2) to produce molecular oxygen (O2), which could be converted into cytotoxicity reactive oxygen species (ROS) by surface-loaded Ce6 under 660 nm laser irradiation, leading to synergistic anticancer effects in vitro and in vivo. Therefore, the application of CCM capsule could be a promising strategy to improve PDT effectiveness. In this study, multifunctional metal-phenolic network (MPN) capsules (denoted as CCM capsules), which contain catalase (CAT) and chlorin e6 (Ce6), were prepared to relieve the hypoxic environment of tumor and enhance the efficacy of photodynamic therapy. [Display omitted]