Effect of a newly synthesized leukotriene antagonist, (E)-2,2-diethyl-3′-2-2-(4-isopropyl) thiazolyl ethenyl succinanilic acid (MCI-826), on immunological liver injury and nephritis in mice

• Published in: Prostaglandins, leukotrienes and essential fatty acids Vol. 47; no. 1; pp. 51 - 57
• Main Authors: Nagai, H., Kitagaki, K., Miura, T., Shimazawa, T., Koda, A.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.09.1992; Elsevier
• Subjects: Animals; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Cyclophosphamide - pharmacology; Glomerulonephritis - etiology; Glomerulonephritis - prevention & control; Kidney - drug effects; Kidney - injuries; Leukotriene Antagonists; Liver - drug effects; Liver - injuries; Male; Medical sciences; Mice; Mice, Inbred DBA; Pharmacology. Drug treatments; Prednisolone - pharmacology; SRS-A - antagonists & inhibitors; Thiazoles - pharmacology; Vasculitis - etiology; Vasculitis - prevention & control; Leukotriene; Chemotherapy; Experimental disease; Treatment; Animal; Arachidonic acid derivatives; Antiinflammatory agent; Hepatic disease; Renal disease; Antagonist; Mechanism of action
• ISSN: 0952-3278; 1532-2823
• DOI: 10.1016/0952-3278(92)90185-L

The effect of a newly synthesized leukotriene antagonist, (E)-2,2-diethyl-3′-2-2-(4-isopropyl) thiazolyl ethenyl succinanilic acid (MCI-826), on liver injury and nephritis in mice was studied. In order to confirm the anti-leukotriene activity of MCI-826, the effect of MCI-826 on leukotriene C 4(LTC 4)- and leukotriene D 4(LTD 4)-induced vasculitis, liver and kidney injury was studied. MCI-826 was found to clearly inhibit LTC 4- and LTD 4-induced vasculitis, as well as liver and kidney injury. In addition to LT-induced reactions, MCI-826 inhibited liver injury induced by injection of either an anti-basic liver protein antibody into DBA/2 mice that had been previously immunized with rabbit IgG or of a bacterial lipopolysaccharide (LPS) into Corynebacterium parvum pretreated DDY mice. Moreover, MCI-826 inhibited nephritis, caused by injecting antiglomerular basement membrane antibody into C57BL/6 mice. These results suggest that MCI-826 can be applied to the treatment of certain tissue inflammatory diseases.