Hydrazone derivatives in agrochemical discovery and development

• Published in: Chinese chemical letters Vol. 35; no. 3; pp. 108207 - 113
• Main Authors: Wang, Ya, Guo, Shengxin, Yu, Lijiao, Zhang, Wei, Wang, Zhenchao, Chi, Yonggui Robin, Wu, Jian
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2024; National Key Laboratory of Green Pesticide,Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Guizhou University,Huaxi District,Guiyang 550025,China%National Key Laboratory of Green Pesticide,Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Guizhou University,Huaxi District,Guiyang 550025,China; Division of Chemistry & Biological Chemistry,School of Physical & Mathematical Sciences,Nanyang Technological University,Singapore 637371,Singapore
• Subjects: Agrochemicals; Biological activity; Hydrazone; Preliminary mechanism; Structure-activity relationship; Hydrazone; Agrochemicals; Preliminary mechanism; Structure-activity relationship; Biological activity
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2023.108207

As a common active substructure, hydrazone has attracted increasing attention and is considered essential for pesticide discovery. It has been widely regarded as a potential insecticidal, antibacterial, antifungal, antiviral, and herbicidal agent. In this review, we highlight the pesticide versatility of hydrazone fragments and provide a comprehensive summary of the biological activity, structure-activity relationship analysis (SARs), and primary mechanism of their analogs. This profile is expected to give valuable information for discovering new pesticides. As a common active substructure, hydrazone has attracted more and more attention and is considered an essential element for pesticide discovery. [Display omitted]