Neuroinflammation: An astrocyte perspective

Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles in health and disease. Recent technologies have uncovered the functional heterogeneity of astrocytes and their extensive interactions with other cell types in the CNS. In this Review, we highlight the intr...

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Bibliographic Details
Published inScience translational medicine Vol. 15; no. 721; p. eadi7828
Main Authors Lee, Hong-Gyun, Lee, Joon-Hyuk, Flausino, Lucas E, Quintana, Francisco J
Format Journal Article
LanguageEnglish
Published United States 08.11.2023
Subjects
Astrocytes - metabolism
Central Nervous System
Humans
Inflammation - metabolism
Neuroglia
Neuroinflammatory Diseases
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Summary:Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles in health and disease. Recent technologies have uncovered the functional heterogeneity of astrocytes and their extensive interactions with other cell types in the CNS. In this Review, we highlight the intricate interactions between astrocytes, other CNS-resident cells, and CNS-infiltrating cells as well as their potential therapeutic value in the context of inflammation and neurodegeneration.
ISSN:1946-6242
DOI:10.1126/scitranslmed.adi7828