Synthesis of bacillamide 3 and its analogue

The bacillamide 1 is a new algaecide from the marine bacterium Bacillus sp. SY-1. Its analogues bacillamide 3 and alkaloid 4 were firstly synthesized effectively from d-alanine. The key step was a coupling reaction via the mixed anhydride. All structures were confirmed by 1H NMR and 13C NMR. The fin...

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Bibliographic Details
Published inChinese chemical letters Vol. 20; no. 10; pp. 1195 - 1197
Main Authors Li, Duo, Yang, Hai Shen, Cui, Qing, Mao, Shen Jie, Xu, Xiao Hua
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.10.2009
State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
Subjects
Bacillamide
Synthesis
Thiazole rings
Tryptamide
Tryptamide
Synthesis
Bacillamide
Thiazole rings
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Summary:The bacillamide 1 is a new algaecide from the marine bacterium Bacillus sp. SY-1. Its analogues bacillamide 3 and alkaloid 4 were firstly synthesized effectively from d-alanine. The key step was a coupling reaction via the mixed anhydride. All structures were confirmed by 1H NMR and 13C NMR. The final compounds were confirmed by 1H NMR, 13C NMR and HRMS and the results are consistent with the reported natural products.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2009.05.014