The effect of benzodiazepine on the increase of oxygen consumption in cold exposed rats

1. 1. Oxygen consumption and rectal temperature of warm and cold acclimated rats were measured after chronic and acute injections of saline or benzodiazepine (diazepam). 2. 2. Benzodiazepine has blocked the increase in oxygen consumption of warm acclimated rats on exposure to cold. 3. 3. After cold...

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Published inComparative biochemistry and physiology. C, Comparative pharmacology Vol. 90; no. 1; pp. 151 - 153
Main Authors Luz, J., Griggio, M.A.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier B.V 1988
New York, NY Pergamon Press
Subjects
Animals
Biological and medical sciences
Body Temperature - drug effects
Cold Temperature
Diazepam - pharmacology
Male
Medical sciences
Neuropharmacology
Oxygen Consumption - drug effects
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Inbred Strains
Vertebrata
Mammalia
Cold
Rat
Thermal accommodation
Animal
Body temperature
Rodentia
Thermoregulation
Benzodiazepine derivatives
Oxygen consumption
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Summary:1. 1. Oxygen consumption and rectal temperature of warm and cold acclimated rats were measured after chronic and acute injections of saline or benzodiazepine (diazepam). 2. 2. Benzodiazepine has blocked the increase in oxygen consumption of warm acclimated rats on exposure to cold. 3. 3. After cold acclimation, the benzodiazepine did not affect the increase in oxygen consumption. 4. 4. Benzodiazepine caused a slight hypothermia when injected chronically, but did not affect rectal temperature over a short period of time.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0306-4492
0742-8413
DOI:10.1016/0742-8413(88)90111-9