Antioxidant activity of synthetic cytokinin analogues: 6-alkynyl- and 6-alkenylpurines as novel 15-lipoxygenase inhibitors

• Published in: Bioorganic & medicinal chemistry Vol. 10; no. 5; pp. 1581 - 1586
• Main Authors: BRATHE, Anders, ANDRESEN, Geir, GUNDERSEN, Lise-Lotte, MALTERUD, Karl E, RISE, Frode
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Science 01.05.2002
• Subjects: Antioxidants - chemical synthesis; Antioxidants - chemistry; Antioxidants - pharmacology; Biological and medical sciences; Cytokinins - chemical synthesis; Cytokinins - chemistry; Cytokinins - pharmacology; Enzyme Inhibitors - chemical synthesis; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Free Radical Scavengers - chemical synthesis; Free Radical Scavengers - chemistry; Free Radical Scavengers - pharmacology; General and cellular metabolism. Vitamins; Glycine max - enzymology; Lipoxygenase Inhibitors; Medical sciences; Pharmacology. Drug treatments; Purines - chemical synthesis; Purines - chemistry; Purines - pharmacology; Structure-Activity Relationship; Purine derivatives; Acetylenic compound; Enzyme; Nitrogen heterocycle; Enzyme inhibitor; Antioxidant; In vitro; Radical scavenger; Free radical; Structure activity relation; Bicyclic compound; Oxidoreductases; Lipoxygenase; Chemical synthesis; Ethylenic compound
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/S0968-0896(01)00427-8

Synthetic cytokinin analogues as well as the well known CKs 6-benzylaminopurine (BAP), kinetin and trans-zeatin were examined for antioxidant activity. The compounds were tested as potential diphenylpicrylhydrazyl (DPPH) scavengers and as inhibitors of 15-lipoxygenase (15-LO). The natural plant hormones were essentially inactive in both assays, but several synthetic analogues have a profound inhibiting effect on 15-lipoxygenase from soybeans. The same compounds were only weak DPPH scavengers and they may therefore be regarded as so-called non antioxidant inhibitors of 15-LO.