Heterocycles from cyclopropenones

• Published in: RSC advances Vol. 12; no. 29; pp. 18615 - 18645
• Main Authors: Aly, Ashraf A, Hassan, Alaa A, Mostafa, Sara M, Mohamed, Asmaa. H, Osman, Esraa M, Nayl, AbdElAziz A
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 22.06.2022; The Royal Society of Chemistry
• Subjects: Chemical reactions; Chemistry; Cycloaddition; Isomerization; Nucleophiles; Organic chemistry; Organometallic compounds; Reagents; Ring opening; Synthesis
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/d2ra03011j

Great attention has been paid to cyclopropenones as they are present in many natural sources. Various synthesized cyclopropenone derivatives also show a wide range of biological activities. The cyclopropenone derivatives undergo a variety of reactions such as ring-opening reactions, isomerization reactions, C-C coupling reactions, C-H activation, cycloaddition reactions, thermal and photo-irradiation reactions, and acid-base-catalyzed reactions under the influence of various chemical reagents (electrophiles, nucleophiles, radicals, and organometallics) and external forces (heat and light). Many previous reviews have dealt with the chemistry and reactions of cyclopropenones. However and to the best of our knowledge, the utility of cyclopropenones in the synthesis of heterocycles has not been reported before. Therefore, it would be interesting to shed light on this new topic. The present review article provides, for the first time, a comprehensive compilation of synthetic methods for the synthesis of various heterocyclic ring systems, as a significant family in the field of organic chemistry. Great attention has been paid to cyclopropenones as they are present in many natural sources.