New Amino-Bisphosphonate Building Blocks in the Synthesis of Bisphosphonic Derivatives Based on Lead Compounds

A facile procedure for the synthesis of new aminobisphosphonate building blocks has been developed. The latter were used in the preparation of conjugates with ursolic, betulonic, betulinic, folic acids, and trolox-the promising antitumor agents.

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Bibliographic Details
Published inPhosphorus, sulfur, and silicon and the related elements Vol. 190; no. 7; pp. 1201 - 1212
Main Authors Becker, Christina S., Chukanov, Nikita V., Grigor'ev, Igor A.
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis 03.07.2015
Taylor & Francis Ltd
Subjects
Bisphosphonates
building blocks
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
conjugation
Lead
lead compounds
Physical Sciences
Science & Technology
DESIGN
CELLS IN-VITRO
RECEPTOR
lead compounds
ANTITUMOR-ACTIVITY
Bisphosphonates
conjugation
ZOLEDRONIC ACID
BREAST-CANCER
ANTICANCER ACTIVITY
URSOLIC ACID
DRUGS
BIOLOGICAL EVALUATION
building blocks
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Summary:A facile procedure for the synthesis of new aminobisphosphonate building blocks has been developed. The latter were used in the preparation of conjugates with ursolic, betulonic, betulinic, folic acids, and trolox-the promising antitumor agents.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ISSN:1042-6507
1563-5325
DOI:10.1080/10426507.2014.979989