Role of sympathetic and parasympathetic mechanisms in formation of secondary cardiac rhythms in rats ontogenesis

• Published in: Journal of evolutionary biochemistry and physiology Vol. 41; no. 1; pp. 87 - 95
• Main Authors: Bursian, A V, Sizonov, V A, Semenova, YuO, Kulaev, B S, Timofeeva, O P, Polyakova, LA, Dmitrieva, LE
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.01.2005
• Subjects: Rodents
• ISSN: 0022-0930; 1608-3202
• DOI: 10.1007/s10893-005-0039-x

In progeny of Wistar rats aged from birth to 3 week, there was studied participation of sympathetic and parasympathetic mechanisms in regulation of cardiac rhythm and its rhythmic oscillations (secondary cardiac rhythms), whose spectral composition was analyzed using rapid Fourier transformation. Consequences, which changed in the process of development, of blockade of β-adrenoreceptors by propranolol, of α-adrenoreceptors by phentolamine, and of muscarinic cholinoreceptors by atropine as well as of chronic desympathization by guanethidine (isobarine). It was found that due to heterochronia in establishment of functions of sympathetic and parasympathetic nervous systems, reactions to blockade of adreno- and cholinoreceptors for the first 3 weeks of postnatal ontogenesis changed not only quantitatively, but also qualitatively. Blockade of adrenoreceptors in newborn animals leads to an increase of power of the rhythm oscillations in all low-frequency diapasons. The baroreflex function of parasympathetic innervation is well expressed as early as in newborns. Tonic function with respect to frequency of heart rate and power of oscillations in the high-frequency diapason becomes evident only by the 3-week age.[PUBLICATION ABSTRACT]