The hepatobiliary transport and short-term biodynamics of radioiodinated chenodeoxycholic acid

• Published in: International journal of nuclear medicine & biology Vol. 11; no. 1; pp. 67,71 - 69,71
• Main Authors: OZKER, K, URGANCIOGLU, I
• Format: Journal Article
• Language: English
• Published: Tarrytown, NY Elsevier Inc 1984; Elsevier
• Subjects: Animals; Bile - metabolism; Biological and medical sciences; Chenodeoxycholic Acid - metabolism; Fundamental and applied biological sciences. Psychology; Iodine Radioisotopes; Isotope Labeling; Kinetics; Liver - diagnostic imaging; Liver - metabolism; Liver. Bile. Biliary tracts; Rabbits; Radionuclide Imaging; Rats; Vertebrates: digestive system; Vertebrata; Mammalia; Radiolabelling; Rat; Bile acid; Liver; Rodentia; Metabolism; Bile
• ISSN: 0047-0740
• DOI: 10.1016/0047-0740(84)90036-6

In recent years, chenodeoxycholic acid has been used for the elimination of gallstones. This study was undertaken to evaluate the usefulness of radioiodine labelled chenodeoxycholic acid as an agent for hepatobiliary investigations. The uptake of [ 125I]chenodeoxycholic acid into various tissues of the rat as a function of time has been studied. This compound was quantitatively taken up by the liver and excreted in the bile to a significant extent. Scintigraphic nonvisualization of the thyroid gland and urinary bladder of the rabbit verified that in vivo release of iodine was insignificant. It was concluded that this compound has a potential value for hepatobiliary studies and merits further investigations.