FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY DETECTS THE INFLAMMATORY PHASE OF SCLEROSING PERITONITIS

• Published in: Peritoneal dialysis international Vol. 26; no. 2; pp. 224 - 230
• Main Authors: Tarzi, Ruth M, Frank, John W, Ahmad, Sohail, Levy, Jeremy B, Brown, Edwina A
• Format: Journal Article
• Language: English
• Published: Milton, ON Multimed 01.03.2006
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Emergency and intensive care: renal failure. Dialysis management; Female; Fluorodeoxyglucose F18; Humans; Intensive care medicine; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Osteoarticular system. Muscles; Peritoneal Dialysis, Continuous Ambulatory - adverse effects; Peritoneum - diagnostic imaging; Peritoneum - pathology; Peritonitis - diagnostic imaging; Peritonitis - etiology; Pharmacology. Drug treatments; Positron-Emission Tomography; Radionuclide investigations; Radiopharmaceuticals; Sclerosis; Kidney disease; Urinary system disease; complications of peritoneal dialysis; Sclerosing peritonitis; Peritoneal dialysis; Extrarenal dialysis; Abdominal disease; FDG-PET scan; Renal failure; Complication; Positron emission tomography; Peritonitis; Positron; Emission tomography; encapsulating sclerosing peritonitis
• ISSN: 0896-8608; 1718-4304
• DOI: 10.1177/089686080602600219

Renal Unit 1 and Department of Nuclear Medicine, 2 Charing Cross Hospital, London, United Kingdom Correspondence to: R. Tarzi, Department of Renal Medicine, Hammersmith Hospital, Du Cane Road, London, W12 0NN, United Kingdom. r.tarzi{at}imperial.ac.uk Objective: We studied the effectiveness of 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting inflammation in known or suspected cases of sclerosing peritonitis in patients on peritoneal dialysis (PD). Design: We undertook FDG-PET scanning in PD patients presenting with symptoms or signs suggestive of sclerosing peritonitis (SP), and in patients on long-term PD with no symptoms of SP. Setting: The study was performed in a PD unit in a tertiary-care hospital. Patients and Methods: Three patients with known or strongly suspected SP underwent FDG-PET scans, 1 within 3 months of presentation with symptoms and 2 who were scanned more than 9 months after presentation. One patient was scanned at an early and a late time point. Five patients who had been on PD for more than 5 years and who were asymptomatic also underwent FDG-PET scanning. Scans were interpreted by a specialist in nuclear medicine. Results: The scan performed in the early stages of SP showed increased peritoneal uptake. However, three scans taken more than 9 months after presentation with suspected SP showed mild peritoneal abnormalities only. One of 5 asymptomatic long-term PD patients showed increased peritoneal uptake associated with loss of ultrafiltration and high transporter status. Conclusions: FDG-PET scanning may be a useful adjunct in the diagnosis of the acute phase of SP. More study is needed to define its role in the diagnosis of SP in asymptomatic PD patients. KEY WORDS: Sclerosing peritonitis; encapsulating sclerosing peritonitis; FDG-PET scan; complications of peritoneal dialysis. Received 30 March 2005; accepted 11 July 2005.