Effects of soman on norepinephrine uptake and electrically stimulated release from human uterine arteries

The effects of soman on the uptake and electrically induced release of norepinephrine (noradrenaline) from isolated human uterine artery have been investigated. Soman did not alter the uptake of norepinephrine by human uterine artery, but reduced the electrically induced release of norepinephrine fr...

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Bibliographic Details
Published inPharmacological research Vol. 25; no. 2; p. 181
Main Authors Hu, C Y, Robinson, C P
Format Journal Article
LanguageEnglish
Published Netherlands 01.02.1992
Subjects
Adult
Arteries - drug effects
Arteries - metabolism
Female
Humans
In Vitro Techniques
Middle Aged
Norepinephrine - pharmacokinetics
Soman - pharmacology
Tritium
Uterus - blood supply
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Summary:The effects of soman on the uptake and electrically induced release of norepinephrine (noradrenaline) from isolated human uterine artery have been investigated. Soman did not alter the uptake of norepinephrine by human uterine artery, but reduced the electrically induced release of norepinephrine from the artery. This reduced norepinephrine release may augment the fall in blood pressure induced by accumulated acetylcholine stimulating muscarinic receptors following cholinesterase inhibition.
ISSN:1043-6618
DOI:10.1016/1043-6618(92)91386-U