Titrimetric determination of vitamin B6 using chloramine-T, bromamine-T, and bromamine-B

Simple titrimetric methods have been developed for determination of the vitamin pyridoxine (PRX) in solution, using aromatic N-haloamines, chloramine-T, bromamine-T, and bromamine-B. The method is based on oxidation of PRX by the N-haloamines; the oxidation involves a 2-electron change. The reaction...

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Bibliographic Details
Published inJournal of the Association of Official Analytical Chemists Vol. 69; no. 1; p. 47
Main Authors Jayaram, B, Made Gowda, N M
Format Journal Article
LanguageEnglish
Published United States 1986
Subjects
Chemical Phenomena
Chemistry
Chloramines
Hydrogen-Ion Concentration
piridoxina
pyridoxine
Pyridoxine - analysis
Solutions
Sulfonamides
Tablets
Temperature
titrimetria
titrimetrie
titrimetry
Tosyl Compounds
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Summary:Simple titrimetric methods have been developed for determination of the vitamin pyridoxine (PRX) in solution, using aromatic N-haloamines, chloramine-T, bromamine-T, and bromamine-B. The method is based on oxidation of PRX by the N-haloamines; the oxidation involves a 2-electron change. The reaction products, pyridoxal and sulfonamides, were identified. The effects of variables, such as pH of the medium and the presence of foreign ions, and pyridoxal, pyridoxalamine, glycerol, and alcohol, on the rate of oxidation were studied. The methods are useful for determining PRX in pharmaceutical formulations and for assaying its cadmium complex. Statistical evaluation showed that analytical results are accurate to within 1%.
Bibliography:Q04
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ISSN:0004-5756
DOI:10.1093/jaoac/69.1.47