Cytogenetic analysis of 10,286 cases with male infertility

Chromosome analysis of 10,286 cases with male infertility and to discuss the genetic causes of male infertility. 10,286 patients with azoospermia and oligoasthenozoospermia were collected in the present center from January 2009 to January 2013.Peripheral blood lymphocyte culture and chromosome analy...

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Published inClinical and experimental obstetrics & gynecology Vol. 44; no. 3; p. 392
Main Authors Chen, H, Gao, X, Shi, L L, Gao, X B
Format Journal Article
LanguageEnglish
Published Canada 01.01.2017
Subjects
Adult
Chromosome Aberrations
Cohort Studies
Cytogenetic Analysis
Humans
Infertility, Male - genetics
Karyotyping
Male
Middle Aged
Polymorphism, Genetic
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Summary:Chromosome analysis of 10,286 cases with male infertility and to discuss the genetic causes of male infertility. 10,286 patients with azoospermia and oligoasthenozoospermia were collected in the present center from January 2009 to January 2013.Peripheral blood lymphocyte culture and chromosome analysis were performed. In all the 10,286 cases with azoospermia and oligoasthenozoospermia, 8,401 cases showed normal karyotype, 538 cases had chromosome polymorphism, accounting for 5.2% and 1,378 cases had chromosomal abnormalities with a frequency of 13.4%; Conclusions: Genetic factors are closely related to the occurrence of azoospermia and oligoasthenozoospermia, and chromosome analysis in patients with male infertility is necessary.
ISSN:0390-6663
DOI:10.12891/ceog3245.2017