Stable isotope labeling of nanomaterials for biosafety evaluation and drug development

• Published in: Chinese chemical letters Vol. 33; no. 7; pp. 3303 - 3314
• Main Authors: Chang, Xue-Ling, Chen, Lingyun, Liu, Boning, Yang, Sheng-Tao, Wang, Haifang, Cao, Aoneng, Chen, Chunying
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.2022; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China%Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission,School of Chemistry and Environment,Southwest Minzu University,Chengdu 610041,China%Institute of Nanochemistry and Nanobiology,Shanghai University,Shanghai 200444,China%CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China,and University of Chinese Academy of Sciences,Beijing 100190,China
• Subjects: Biomedical effects; Carbon nanomaterials; Metal oxide nanoparticles; Nanotoxicity; Quantification; Stable isotope labeling; Metal oxide nanoparticles; Nanotoxicity; Biomedical effects; Stable isotope labeling; Quantification; Carbon nanomaterials
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2022.03.057

Quantitative information, such as environmental migration, absorption, biodistribution, biotransformation, and elimination, is fundamental and essential for the nanosafety evaluations of nanomaterials. Due to the complexity of biological and environmental systems, it is challenging to develop quantitative approaches and tools that could characterize intrinsic behaviors of nanomaterials in the organisms. The isotopic tracers are ideal candidates to tune the physical properties of nanomaterials while preserving their chemical properties. In this review article, we summarized the stable isotope labeling methods of nanomaterials for evaluating their environmental and biological effects. The skeleton labeling protocols of carbon nanomaterials and metal/metal oxide nanoparticles were introduced. The advantages and disadvantages of stable isotope labeling were discussed in comparison with other quantitative methods for nanomaterials. The quantitative information of nanomaterials in environmental and biological systems was summarized along with the biosafety data. The benefits for drug development of nanomedicine were analyzed based on the targeting effects, persistent accumulation, and safety. Finally, the challenges and future perspectives of stable isotope labeling in nanoscience and nanotechnology were discussed. We review the advances in the stable isotope labeling of nanomaterials for evaluating their environmental and biological effects. The labeling protocols, the advantages/disadvantages of stable isotope labeling, and the quantitative information of nanomaterials in environmental and biological systems are summarized. The challenges and future perspectives of stable isotope labeling in nanoscience and nanotechnology are discussed. [Display omitted]