Dentin-desensitizing biomaterials

• Published in: Chinese chemical letters Vol. 34; no. 8; pp. 108060 - 56
• Main Authors: Wang, Qihui, Luan, Jiayi, Zhao, Zhilong, Kong, Weihui, Zhang, Congxiao, Ding, Jianxun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.08.2023; Department of Stomatology,the First Hospital of Jilin University,Changchun 130061,China; VIP Integrated Department,Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,School and Hospital of Stomatology,Jilin University,Changchun 130021,China%Department of Stomatology,the First Hospital of Jilin University,Changchun 130061,China%Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China; Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China%Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
• Subjects: Biomaterial; Dental nerve blockade; Dentin hypersensitivity; Dentinal tubule closure; Regenerative medicine; Dentinal tubule closure; Biomaterial; Dentin hypersensitivity; Regenerative medicine; Dental nerve blockade
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2022.108060

Dentin hypersensitivity (DH) associated with dentinal tubule exposure is one of the most common causes of toothache with a rapid onset and short duration. Medication, filling repair, laser irradiation, crown therapy, and desensitizing toothpaste are standard clinical treatment strategies, but unsatisfactory treatment modalities are marked by long-term administration, poor dentinal tubule closure, microleakage, and the development of secondary caries. To improve the treatment efficiency of DH, numerous organic or inorganic biomaterials have been developed to relieve toothache and reverse the instability of desensitization. Biomaterials are expected to participate in dental remineralization to achieve desensitization. This review discusses various biomaterials for DH therapy based on different desensitization mechanisms, including dentinal tubule closure and dental nerve blockade, and presents a perspective on the underlying future of dentin regeneration medicine for DH therapy. [Display omitted] This review discusses various biomaterials for dentin hypersensitivity therapy based on different desensitization mechanisms, including dentinal tubule closure and dental nerve blockade, and presents a perspective on their development and potential clinical applications.