6-Bromo-2’-(2-chlorobenzylidene)nicotinohydrazide and 6-Bromo-2’-(3-bromo-5-chloro-2-hydroxybenzylidene) nicotinohydrazide Methanol Solvate: Synthesis, Characterization, Crystal Structures and Antimicrobial Activities

• Published in: Acta chimica Slovenica Vol. 68; no. 1; pp. 65 - 71
• Main Author: Zhu, Hai-Yun
• Format: Journal Article
• Language: English
• Published: Slovenian Chemical Society 01.03.2021
• Subjects: antimicrobial activity; hydrazone; hydrogen bonding; synthesis; x-ray crystal structure
• ISSN: 1580-3155; 1318-0207; 1580-3155
• DOI: 10.17344/acsi.2020.6138

Two newly synthesized nicotinohydrazones, 6-bromo-2’-(2-chlorobenzylidene)nicotinohydrazide (1) and 6-bromo-2’-(3-bromo-5-chloro-2-hydroxybenzylidene)nicotinohydrazide methanol solvate (2), have been obtained and structurally characterized by spectroscopic method and single crystal X-ray determination. The molecules in both compounds are in E configuration regarding to the azomethine groups. The molecules of compound 1 are linked via hydrogen bonds of N−H∙∙∙O, generating one dimensional chains running along the c-axis direction. The hydrazone molecules of compound 2 are linked by methanol molecules via hydrogen bonds of N−H∙∙∙O and O−H∙∙∙N, generating dimers. The in vitro antimicrobial activities of these compounds indicate that they are interesting antibacterial agents.