Reactive extraction and reextraction of penicillin with different carriers

The extraction and reextraction of Penicillin G was investigated with different reactive components. The degrees E R of reextraction and E G extraction + reextraction were evaluated as a function of the pH value, carrier and penicillin concentrations. Besides Amberlite LA-2, nine different reactive...

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Bibliographic Details
Published inJournal of biotechnology Vol. 5; no. 4; pp. 293 - 303
Main Authors Likidis, Z., Schügerl, K.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 1987
Subjects
benzylpenicillin
Ion exchange extraction
Ion pair extraction
Penicillin G
Reactive extraction
Penicillin G
Reactive extraction
Ion pair extraction
Ion exchange extraction
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Summary:The extraction and reextraction of Penicillin G was investigated with different reactive components. The degrees E R of reextraction and E G extraction + reextraction were evaluated as a function of the pH value, carrier and penicillin concentrations. Besides Amberlite LA-2, nine different reactive components were tested and diisotridecylamine was found to be the most suitable one. The quaternary ammonium salt Adogen 464 is suitable also for the extraction of penicillin. However, the reextraction is incomplete. Therefore, sodium salt of p-toluene sulfonic acid was used as counter-ion, and it was regenerated by NaOH or Cl − anion. The advantages of the use of quaternary ammonium salts are discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0168-1656
1873-4863
DOI:10.1016/0168-1656(87)90026-5