Harnessing regulatory T cells to establish immune tolerance

Engineered regulatory T (T ) cells have emerged as precision therapeutics aimed at inducing immune tolerance while reducing the risks associated with generalized immunosuppression. This Viewpoint highlights the opportunities and challenges for engineered T cell therapies in treating autoimmune and o...

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Bibliographic Details
Published inScience translational medicine Vol. 16; no. 738; p. eadm8859
Main Authors Ho, Patrick, Cahir-McFarland, Ellen, Fontenot, Jason D, Lodie, Tracey, Nada, Adel, Tang, Qizhi, Turka, Laurence A, Bluestone, Jeffrey A
Format Journal Article
LanguageEnglish
Published United States 13.03.2024
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Summary:Engineered regulatory T (T ) cells have emerged as precision therapeutics aimed at inducing immune tolerance while reducing the risks associated with generalized immunosuppression. This Viewpoint highlights the opportunities and challenges for engineered T cell therapies in treating autoimmune and other inflammatory diseases.
ISSN:1946-6242
DOI:10.1126/scitranslmed.adm8859