Transition metal mediated carbonylative benzannulations
In carbonylative benzannulations, feedstock carbon monoxide is converted to a benzene ring, which is one of the most fundamentally important and common rings in natural products and pharmaceutical compounds. Carbon monoxide, however, is rather inert in the absence of transition metals. Historically,...
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| Published in | Organic & biomolecular chemistry Vol. 15; no. 36; pp. 749 - 754 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
20.09.2017
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| Online Access | Get full text |
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| Summary: | In carbonylative benzannulations, feedstock carbon monoxide is converted to a benzene ring, which is one of the most fundamentally important and common rings in natural products and pharmaceutical compounds. Carbon monoxide, however, is rather inert in the absence of transition metals. Historically, carbonylative benzannulations have been mediated by stoichiometric chromium and iron in the form of Fischer carbenes. Recently, a number of transition metal-catalyzed carbonylative benzannulations have been developed, and almost all of them involve rhodium catalysts. This review will briefly discuss the mechanism and applications of carbonylative benzannulations involving Fischer carbenes and compare them with the more recent transition metal-catalyzed processes, including [3 + 2 + 1] cycloadditions, [5 + 1] cycloadditions, and other less common cycloadditions.
This review summarizes novel building blocks recently developed for transition metal-catalyzed carbonylative benzannulations. |
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| Bibliography: | Wangze Song received his B.S. degree in Chemistry from Nankai University, where he worked in Professor Chi Zhang's lab. He earned his M.S. degree in Chemistry from Zhejiang University under the supervision of Professors Yanguang Wang and Ping Lu. He received his Ph.D. degree in 2016 from University of Wisconsin-Madison working with Professor Weiping Tang. He is currently an associate professor at Dalian University of Technology. Jitian Liu received his B.S. degree in 2009 and M.S. degree in 2012 both from Ocean University of China working with Professor Caifeng Bi. He received his Ph.D. degree in 2017 from Tianjin University under the supervision of Professors Richard Hsung and Yu Tang. He studied in Professor Weiping Tang's laboratory at University of Wisconsin-Madison as a joint student from 2015 to 2016. He is currently a postdoctoral fellow at Peking University. Shuojin Wang received his B.S. degree in 2004 and Ph.D. degree in 2009 both from Huazhong University of Science & Technology working with Professor Nie Jin. He then worked for WuXi AppTec from 2009 to 2014. He became an assistant professor at Hainan Medical University since 2014. He worked in Professor Weiping Tang's laboratory at the University of Wisconsin-Madison as a visiting scholar from 2015 to 2016. Stephanie Blaszczyk obtained her B.S. degree in Chemistry from Rockford University in 2013 while working with Professor Matthew Bork. Following graduation, she entered the industrial sector to work for Geneva Laboratories and then Tate & Lyle. Currently enrolled as a Ph. D. student at the University of Wisconsin-Madison, Stephanie is now developing new synthetic methods under the direction of Professor Weiping Tang. Weiping Tang received his B.S. degree from Peking University, M.S. degree from New York University, and Ph.D. degree from Stanford University. He was a HHMI postdoctoral fellow at Harvard University. He is currently a professor in the School of Pharmacy and Department of Chemistry at the University of Wisconsin-Madison. His group is interested in developing new synthetic methods, natural product synthesis, medicinal chemistry and chemical biology. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 1477-0520 1477-0539 |
| DOI: | 10.1039/c7ob01000a |