Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity

Protein tyrosine phosphatase 1B (PTP1B) has received considerable attention from the drug industry as a potential treatment for diabetes mellitus. Mangiferin has been reported to possess significant antidiabetic activity. Based on the previous study, eight new mangiferin derivates were synthesized a...

Full description

Saved in:
Bibliographic Details
Published inChinese chemical letters Vol. 18; no. 11; pp. 1323 - 1326
Main Authors Hu, Hong Gang, Wang, Ming Juan, Zhao, Qing Jie, Yu, Shi Chong, Liu, Chao Mei, Wu, Qiu Ye
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.11.2007
Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China%Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
Department of Chemistry, College of Science, Wayne State University, Detroit, MI 48202, United States
Subjects
Derivates
Inhibition
Mangiferin
Protein tyrosine phosphatase 1B
Protein tyrosine phosphatase 1B
Derivates
Inhibition
Mangiferin
Online AccessGet full text

Cover

More Information
Summary:Protein tyrosine phosphatase 1B (PTP1B) has received considerable attention from the drug industry as a potential treatment for diabetes mellitus. Mangiferin has been reported to possess significant antidiabetic activity. Based on the previous study, eight new mangiferin derivates were synthesized and evaluated for their PTP1B inhibitory activity. Some of them displayed good inhibitory activity on PTP1B.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2007.09.011