Parecoxib as an Alternative in COX-2 Hypersensitivity

The group of non-steroidal anti-inflammatory drugs (NSAIDs) is commonly involved in hypersensitivity reactions. In clinical practice the physician is often faced with the need to choose an alternative anti-inflammatory agent for a patient who has suffered a hypersensitivity reaction to a NSAID. The...

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Bibliographic Details
Published inInternational journal of immunopathology and pharmacology Vol. 21; no. 1; pp. 233 - 235
Main Authors Colanardi, M.C., Nettis, E., Traetta, P., Delle Donne, P., Ferrannini, A., Vacca, A.
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.2008
Subjects
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Cyclooxygenase 2 Inhibitors - adverse effects
Cyclooxygenase Inhibitors - therapeutic use
Drug Hypersensitivity - etiology
Female
Humans
Isoxazoles - therapeutic use
Middle Aged
parecoxib
COX-2 inhibitors
tolerability
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Summary:The group of non-steroidal anti-inflammatory drugs (NSAIDs) is commonly involved in hypersensitivity reactions. In clinical practice the physician is often faced with the need to choose an alternative anti-inflammatory agent for a patient who has suffered a hypersensitivity reaction to a NSAID. The most common approach to choosing the safest NSAID is to perform a challenge test. Parecoxib is the first injectable COX-2 selective inhibitor indicated for the treatment of acute postoperative pain. The authors report the case of a patient with a history of cutaneous adverse reactions to different classes of NSAIDs, including selective COX-2 inhibitors, who underwent and tolerated challenge with parecoxib.
ISSN:0394-6320
2058-7384
DOI:10.1177/039463200802100127