A convenient microwave-assisted synthesis of cinchona alkaloid-derived ligands

An efficient synthesis of cinchona alkaloid-derived ligands based on solvent-free microwave-assisted reaction was described. The coupling of 1,4-dichlorophthalazine or 3,6-dichloropyridazine with quinine, cinchonine or cinchonidine provide bis- or mono-cinchona alkaloid-derived ligands in moderate t...

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Bibliographic Details
Published inChinese chemical letters Vol. 19; no. 12; pp. 1440 - 1444
Main Authors Wang, Hai Bo, Wang, Ping An, Wang, Quan Jun, Sun, Xiao Li, Jing, Lin Lin
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.12.2008
Department of Chemistry,School of Pharmacy,Fourth Military Medical University,Xi'an 710032,China
Subjects
AD reaction
Cinchona alkaloids
Solvent-free microwave synthesis
Solvent-free microwave synthesis
AD reaction
Cinchona alkaloids
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Summary:An efficient synthesis of cinchona alkaloid-derived ligands based on solvent-free microwave-assisted reaction was described. The coupling of 1,4-dichlorophthalazine or 3,6-dichloropyridazine with quinine, cinchonine or cinchonidine provide bis- or mono-cinchona alkaloid-derived ligands in moderate to good yields (52–89%) within 15 min under optimum microwave conditions.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2008.09.049