Near-infrared small molecular fluorescent dyes for photothermal therapy

• Published in: Chinese chemical letters Vol. 30; no. 7; pp. 1353 - 1360
• Main Authors: Chen, Yisha, Li, Li, Chen, Weijie, Chen, Haiyan, Yin, Jun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.2019; Department of Biomedical Engineering, School of Engineering, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China%Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China
• Subjects: BODIPY; Cyanine; Near-infrared fluorescent dyes; Photothermal therapy; Phthalocyanine; Photothermal therapy; Near-infrared fluorescent dyes; Phthalocyanine; BODIPY; Cyanine
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2019.02.003

This review aims to provide a summary of the progress in fluorescent dyes for photothermal therapy in recent years and it is classified according to the structure of organic molecules including cyanines, phthalocyanines, rhodamine analogues and BODIPYs. [Display omitted] Near-infrared (NIR) fluorescent dyes based on small organic molecules are characterized with low cytotoxicity, good biocompatibility and minimum interference from auto-fluorescence background, which are widely used in tumor diagnosis. Intensive research on molecular properties and photothermal properties of fluorescent dyes have been explored for non-invasive photothermal treatment of cancer. In this review, we focus on the development of imaging-induced photothermal therapy of small molecules and classification according to the structures of organic molecules including cyanines, phthalocyanines, rhodamine analogues and BODIPYs.