Multi-Modal Imaging Including Optical Coherence Tomography Angiography in Patients With Posterior Multifocal Placoid Pigment Epitheliopathy

• Published in: Ophthalmic surgery, lasers & imaging Vol. 48; no. 9; pp. 727 - 733
• Main Authors: Werner, Jens Ulrich, Enders, Christian, Lang, Gerhard Klaus, Lang, Gabriele Elisabeth
• Format: Journal Article
• Language: English
• Published: United States SLACK INCORPORATED 01.09.2017
• Subjects: Adolescent; Adult; Angiography; Choroid - diagnostic imaging; Choroiditis - diagnostic imaging; Circulation; Coherence; Diagnostic systems; Eye (anatomy); Eye diseases; Eyes & eyesight; Female; Fluorescein; Fluorescein Angiography - methods; Headaches; Humans; Imaging; Ischemia - diagnostic imaging; Male; Medical imaging; Multimodal Imaging; Optical Coherence Tomography; Optical Imaging - methods; Pathogenesis; Patients; Photography; Photography - methods; Retina; Retina - diagnostic imaging; Tomography; Tomography, Optical Coherence - methods; Young Adult
• ISSN: 2325-8160; 2325-8179
• DOI: 10.3928/23258160-20170829-07

New imaging methods provide novel insights into the pathogenesis of acute posterior multifocal placoid pigment epitheliopathy (APMPPE). Four patients (eight eyes) in acute, subacute, and late phases of the disease were analyzed with multi-modal imaging methods including optical coherence tomography angiography (OCTA), structural OCT, fundus photography, and fundus autofluorescence. One patient was observed during the entire disease course. In acute and subacute phases of the disease, an early blockage in fluorescein angiography was found. OCTA showed perfusion defects in choriocapillaris and choroid slabs. During the course of disease, perfusion deficits observed in OCTA imaging resolved first in the choroid and then in the choriocapillaris slab. Multi-modal imaging including OCTA supports the thesis that the underlying pathology of APMPPE is an inflammatory impairment of the choroidal circulation with secondary damage to the outer retina. OCTA might be able to replace fluorescein and indocyanine angiography in the diagnostic work-up of APMPPE. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:727-733.].