Structure and Radioprotective Activity of Mercaptoacetyl Hydrazones of 6-Deoxy- and 2-(Acethylamino)aldoses

The condensation products of natural monosaccharides L-fucose, L-rhamnose, N -acetylamino-D-glucose and N -acetylamino-D-mannose with thioglycolic acid hydrazide have a cyclic 1,3,4-thiadiazine structure or are presented in solution in DMSO- d 6 by a tautomeric mixture of pyranose and 1,3,4-thiadiaz...

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Published inRussian journal of general chemistry Vol. 91; no. 4; pp. 661 - 665
Main Authors Lagoda, I. V., Ershov, А. Y., Drachov, I. S., Yakunchikova, Е. A., Martynenkov, А. А., Kopanitsa, M. A., Yakimansky, А. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.04.2021
Springer Nature
Springer
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
Condensates
Dextrose
Glucose
Hydrazones
Mannose
Monosaccharides
Physical Sciences
Science & Technology
radioprotective activity
thiol-containing monosaccharides
ring-ring tautomerism
NANOPARTICLES
THERAPY
PRODUCTS
CONDENSATION
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Summary:The condensation products of natural monosaccharides L-fucose, L-rhamnose, N -acetylamino-D-glucose and N -acetylamino-D-mannose with thioglycolic acid hydrazide have a cyclic 1,3,4-thiadiazine structure or are presented in solution in DMSO- d 6 by a tautomeric mixture of pyranose and 1,3,4-thiadiazine forms. It was shown that L-rhamnose and N -acetylamino-D-mannose mercaptoacetyl hydrazones exhibit high radioprotective activity, increasing the survival rate of mortally irradiated mice by 35–45%.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363221040137