Adsorption Capacity and Biological Activity of Synthetic Zeolites

The study investigates the physicochemical, porous/textural, and adsorptive properties, as well as the biological activity of BEA, RHO, PAU, and FAU(Y) synthetic zeolites. The adsorption capacity of the zeolites for oxytocin, lysozyme, and albumin—markers of low- and medium-molecular-weight patholog...

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Bibliographic Details
Published inPetroleum chemistry Vol. 63; no. 7; pp. 790 - 797
Main Authors Ul’yanova, N. Yu, Brazovskaya, E. Yu, Golubeva, O. Yu, Shamova, O. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.07.2023
Springer
Springer Nature B.V
Subjects
Adsorption
Adsorptivity
Albumin
Biocompatibility
Biological activity
Cells
Chemistry
Chemistry and Materials Science
Endothelial cells
Industrial Chemistry/Chemical Engineering
Lysozyme
Toxicity
Zeolites
adsorption
zeolites
proteins
cytotoxicity
hemolytic activity
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Summary:The study investigates the physicochemical, porous/textural, and adsorptive properties, as well as the biological activity of BEA, RHO, PAU, and FAU(Y) synthetic zeolites. The adsorption capacity of the zeolites for oxytocin, lysozyme, and albumin—markers of low- and medium-molecular-weight pathological proteins—was measured. The concentration-dependent effects of the zeolites on the viability of human endothelial cells (Ea.hy926) were evaluated. At concentrations of 2.5 to 10 mg/mL, the Y zeolite was found to exhibit no pronounced cytotoxicity. In the presence of the BEA, the cell viability decreased to 80% even at 2.5 mg/mL. The RHO and PAU were shown to have the highest cytotoxicity and significantly inhibit the growth of human cells (down to 23–35%). The study demonstrated that only BEA and Y, among the synthetic zeolites tested, have good biomedical potential due to their high adsorption capacity, low hemolytic activity, and low cytotoxicity.
ISSN:0965-5441
1555-6239
DOI:10.1134/S096554412305002X