Ratiometric fluorescence and visual sensing of ATP based on gold nanocluster-encapsulated metal-organic framework with a smartphone

• Published in: Chinese chemical letters Vol. 34; no. 8; pp. 108093 - 235
• Main Authors: Zhou, Xiaomeng, Wang, Xinjie, Shang, Li
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.08.2023; State Key Laboratory of Solidification Processing,School of Materials Science and Engineering,Northwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU),Xi'an 710072,China%Queen Mary University of London Engineering School,Northwestern Polytechnical University,Xi'an 710072,China%State Key Laboratory of Solidification Processing,School of Materials Science and Engineering,Northwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU),Xi'an 710072,China; NPU-QMUL Joint Research Institute of Advanced Materials and Structures(JRI-AMAS),Northwestern Polytechnical University,Xi'an 710072,China
• Subjects: ATP; Fluorescence sensors; Gold nanoclusters; Metal-organic frameworks; Gold nanoclusters; Metal-organic frameworks; ATP; Fluorescence sensors
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2022.108093

Adenosine triphosphate (ATP) plays an important role in various biological processes and the ATP level is closely associated with many diseases. Herein, we designed a novel dual-emissive fluorescence nanoplatform for ATP sensing based on red emissive europium metal-organic framework (Eu-MOF) and blue emissive gold nanoclusters (AuNCs). The presence of ATP causes the decomposition of Eu-MOF owing to strong affinity of Eu3+ with ATP. As a result, the red emission of Eu-MOF decreases while the blue emission of AuNCs remains unchanged. The distinct red/blue emission intensity change enables the establishment of a ratiometric fluorescent and visual sensor of ATP. Moreover, a fluorescent paper-based sensor was fabricated with the ratiometric ATP probes, which enabled easy-to-use and visual detection of ATP in serum samples with a smartphone. A novel dual-emissive fluorescence nanoplatform was designed based on red emissive europium metal-organic framework and blue emissive gold nanoclusters. The distinct red/blue emission intensity change enables the establishment of a ratiometric fluorescent and visual sensor of ATP. [Display omitted]