Synthesis, DNA binding and topoisomerase inhibition of mononaphthalimide homospermidine derivatives

• Published in: Chinese chemical letters Vol. 19; no. 5; pp. 509 - 512
• Main Authors: Tian, Zhi Yong, Ma, Hong Xia, Xie, Song Qiang, Wang, Xue, Zhao, Jin, Wang, Chao Jie, Gao, Wen Yuan
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.05.2008; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China; Institute of Natural Products & Medicinal Chemistry, Henan University, Kaifeng 475001, China%Institute of Natural Products & Medicinal Chemistry, Henan University, Kaifeng 475001, China%Chemistry Department, Henan University, Kaifeng 475001, China%School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
• Subjects: Bioevalution; Polyamine conjugate; Synthesis; Polyamine conjugate; Bioevalution; Synthesis
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2008.03.006

Two novel mononaphthalimide homospermidine derivatives ( 2a, 2b) with three or four methylene unit as linkages were synthesized and evaluated for cytotoxicity against human leukemia K562, murine melanoma B16 and Chinese hamster ovary CHO cell lines. The presence of homospermidine motif could greatly elevate the potency of 1,8-naphthalimide. Conjugate 2b with longer spacer exhibited higher in vitro cytotoxicity than 2a. The DNA binding experiments indicated that conjugates 2b could bind to herring sperm DNA. The topoisomerase II poison trials revealed that 2b could inhibit the activity of top. II.