Use of a Microsoft Excel based add-in program to calculate plasma sinistrin clearance by a two-compartment model analysis in dogs

• Published in: Research in veterinary science Vol. 100; pp. 263 - 264
• Main Authors: Steinbach, Sarah M.L., Sturgess, Christopher P., Dunning, Mark D., Neiger, Reto
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2015; Elsevier Limited
• Subjects: Animals; Biomarkers - blood; Dogs; Glomerular filtration rate; Glomerular Filtration Rate - veterinary; Half-Life; Inulin, sinistrin; Kidney - physiology; Kidney Function Tests - veterinary; Oligosaccharides - blood; Oligosaccharides - pharmacokinetics; Pharmacokinetic; Plasma; Renal function; Small animals; Software; Standard deviation; Studies; Veterinary medicine; Renal function; Inulin, sinistrin; Small animals; Pharmacokinetic; Glomerular filtration rate
• ISSN: 0034-5288; 1532-2661
• DOI: 10.1016/j.rvsc.2015.05.003

•Plasma clearance of sinistrin can be used to estimate glomerular filtration rate in dogs.•PKSolver is a Microsoft Excel add-in that can be used to calculate sinistrin clearance.•Results gained from PKSolver compared to Inusoft are nearly identical.•PKSolver is a valuable tool for pharmacokinetic analysis in veterinary medicine. Assessment of renal function by means of plasma clearance of a suitable marker has become standard procedure for estimation of glomerular filtration rate (GFR). Sinistrin, a polyfructan solely cleared by the kidney, is often used for this purpose. Pharmacokinetic modeling using adequate software is necessary to calculate disappearance rate and half-life of sinistrin. The purpose of this study was to describe the use of a Microsoft excel based add-in program to calculate plasma sinistrin clearance, as well as additional pharmacokinetic parameters such as transfer rates (k), half-life (t1/2) and volume of distribution (Vss) for sinistrin in dogs with varying degrees of renal function.