Optimization of continuous-flow diphenyldiazomethane synthesis: an integrated undergraduate chemistry experiment

We present a challenging flow-chemistry experiment concerning the synthesis of diphenyldiazomethane using the Omura-Sharma-Swern oxidation, that we have developed and used in our second-year undergraduate lab classes over the past seven years. The experiment integrates a number of different aspects...

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Bibliographic Details
Published inJournal of flow chemistry Vol. 11; no. 1; pp. 59 - 66
Main Authors van Summeren, Luuk T. C. G., Gerretzen, Jan, Rutjes, Floris P. J. T., Bloemberg, Tom G.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.03.2021
Subjects
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Green Chemistry
Industrial Chemistry/Chemical Engineering
Inorganic Chemistry
Nanochemistry
Organic Chemistry
Diphenyldiazomethane
Chemical education
DoE
Experimental design
Flow chemistry
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Summary:We present a challenging flow-chemistry experiment concerning the synthesis of diphenyldiazomethane using the Omura-Sharma-Swern oxidation, that we have developed and used in our second-year undergraduate lab classes over the past seven years. The experiment integrates a number of different aspects and concepts of chemistry that are traditionally taught as separate subjects in undergraduate chemical education: organic synthesis, quantitative chemical analysis, design of experiments, optimization, statistical modelling, computer programming and continuous-flow processes.
ISSN:2062-249X
2063-0212
DOI:10.1007/s41981-020-00107-4