25-hydroxyvitamin D-1α-hydroxylase in normal and malignant colon tissue

Vitamin D affects calcium metabolism and prevents proliferation of colon cells in vitro. In human beings the main circulating form of vitamin D is 25-hydroxyvitamin D; to regulate calcium homoeostasis, this form must be converted to 1α, 25-dihydroxyvitamin D by 1α-hydroxylation in the kidney with 25...

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Bibliographic Details
Published inLancet (British edition) Vol. 357; no. 9269; pp. 1673 - 1674
Main Authors Tangpricha, Vin, Flanagan, John N, Whitlatch, Lyman W, Tseng, Chi C, Chen, Tai C, Holt, Peter R, Lipkin, Martin S, Holick, Michael F
Format Journal Article Conference Proceeding
LanguageEnglish
Published London Elsevier Ltd 26.05.2001
Lancet
Subjects
Biological and medical sciences
General and cellular metabolism. Vitamins
Medical sciences
Pharmacology. Drug treatments
Colonic disease
Human
Prevention
Biochemical analysis
Carcinoma
Vitamin D
Digestive diseases
Intestinal disease
Malignant tumor
Colon
Mechanism of action
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Summary:Vitamin D affects calcium metabolism and prevents proliferation of colon cells in vitro. In human beings the main circulating form of vitamin D is 25-hydroxyvitamin D; to regulate calcium homoeostasis, this form must be converted to 1α, 25-dihydroxyvitamin D by 1α-hydroxylation in the kidney with 25-hydroxyvitamin D-1α-hydroxylase. Cultured transformed colon cancer cells can convert 25-hydroxyvitamin D 3 to 1α,25-dihydroxyvitamin D 3. We identified messenger RNA (mRNA) for 25-hydroxyvitamin D-1α-hydroxylase in normal colon tissue and in malignant and adjacent normal colon tissue. These findings support the notion that vitamin D might have a role in cell growth regulation and cancer protection, and might be the explanation for why the risk of dying from colorectal cancer is highest in areas with the least amount of sunlight.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(00)04831-5