From the archives of the AFIP. Malignant pleural mesothelioma: radiologic-pathologic correlation

Malignant pleural mesothelioma (MPM) is a rare malignant neoplasm that typically affects individuals occupationally exposed to asbestos through a variety of industries. The patients experience an insidious onset of symptoms, including dyspnea, chest pain, cough, malaise, and weight loss. The patholo...

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Bibliographic Details
Published inRadiographics Vol. 16; no. 3; p. 613
Main Authors Miller, B H, Rosado-de-Christenson, M L, Mason, A C, Fleming, M V, White, C C, Krasna, M J
Format Journal Article
LanguageEnglish
Published United States 01.05.1996
Subjects
Aged
Humans
Male
Mesothelioma - diagnostic imaging
Mesothelioma - pathology
Mesothelioma - therapy
Pleural Neoplasms - diagnostic imaging
Pleural Neoplasms - pathology
Pleural Neoplasms - therapy
Tomography, X-Ray Computed
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Summary:Malignant pleural mesothelioma (MPM) is a rare malignant neoplasm that typically affects individuals occupationally exposed to asbestos through a variety of industries. The patients experience an insidious onset of symptoms, including dyspnea, chest pain, cough, malaise, and weight loss. The pathologic diagnosis of MPM is difficult, and special stains or immunohistochemical or ultrastructural analysis may be required to differentiate MPM from metastatic adenocarcinoma. The tumor affects both the parietal and visceral pleural surfaces and progresses to encase the lung and invade the lung, mediastinum, and chest wall. Radiologically, MPM manifests as unilateral pleural effusion, pleural nodules, or pleural masses. Imaging studies are useful for diagnosis and staging in patients who are potential surgical candidates. Although a variety of multimodality therapies are available and radical surgical procedures have been developed, the prognosis remains dismal.
ISSN:0271-5333
DOI:10.1148/radiographics.16.3.8897628