Graphene-based hemostatic sponge

• Published in: Chinese chemical letters Vol. 33; no. 2; pp. 703 - 713
• Main Authors: Wu, Bingxin, Du, Fanglin, A, Wenjing, Li, Guofeng, Wang, Xing
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2022; State Key Laboratory of Organic-Inorganic Composites,Beijing Laboratory of Biomedical Materials,Beijing University of Chemical Technology Beijing,100029,China
• Subjects: Coagulation stimulation; Composite materials; Graphene; Hemostatic sponge; Synergistic effect; Hemostatic sponge; Composite materials; Synergistic effect; Graphene; Coagulation stimulation
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2021.06.029

Graphene-based sponge is a novel hemostatic material prepared by chemical cross-link of graphene oxide. It has a fast fluid absorption capacity to quickly absorb blood from wounds, activate clotting pathways, and achieve rapid hemostasis. In addition, graphene-based sponge is also a good platform carrier. It can be prepared by organic cross-linking, compounding with inorganic clay, and adding bioactive factors to enhance coagulation stimulation. By these methods, the hemostatic performance of the sponge is further improved, which shows great potential for application in the field of trauma hemostasis. This article reviews the research progress of graphene-based sponges from three different preparation strategies (organic cross-linking, inorganic compounding and adding bioactive factor), summarizes their hemostatic mechanisms, and prospects the development of graphene-based hemostatic sponges. Graphene oxide is an excellent material with 2D sheet structure, charge stimuli, easy functionalization, electrical conduction and thermal conduction properties, which shows great potential in the field of hemostasis. This article reviews the research progress of graphene-based hemostatic sponges from three different preparation strategies (organic cross-linking, inorganic compounding and adding bioactive factor), and prospects the development of graphene-based sponges. [Display omitted]