Co-NC as adsorbent and matrix providing the ability of MALDI MS to analyze volatile compounds

• Published in: Chinese chemical letters Vol. 32; no. 1; pp. 62 - 65
• Main Authors: Li, Shumu, Liu, Jian’an, Sun, Jiping, Wang, Zhenpeng, Wang, Kai, Guo, Lei, Yang, Shuliang, Wei, Jinchao, Zheng, Xiangjun, Zhao, Zhenwen
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2021; Graduate School,University of Chinese Academy of Sciences,Beijing 100049,China%Beijing Key Laboratory of Energy Conversion and Storage Materials,College of Chemistry,Beijing Normal University,Beijing 100875,China%State Key Laboratory of Toxicology and Medical Countermeasures,and Laboratory of Toxicant Analysis,Academy of Military Medical Sciences,Beijing 100850,China; Beijing National Laboratory for Molecular Sciences,CAS Research/Education Center for Excellence in Molecular Sciences,Key Laboratory of Analytical Chemistry for Living Biosystems,Institute of Chemistry,Chinese Academy of Sciences,Beijing Mass Spectrum Center,Beijing 100190,China%Beijing National Laboratory for Molecular Sciences,CAS Research/Education Center for Excellence in Molecular Sciences,Key Laboratory of Analytical Chemistry for Living Biosystems,Institute of Chemistry,Chinese Academy of Sciences,Beijing Mass Spectrum Center,Beijing 100190,China
• Subjects: Adsorbent; Co-NC; MALDI MS; Matrix; Volatile compounds; Matrix; Volatile compounds; Adsorbent; Co-NC; MALDI MS
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2020.09.026

[Display omitted] Co and N doped porous carbon (Co-NC) material, which is derived from a coordination compound, can simultaneously act as adsorbent of volatile compounds and as matrix of MALDI MS, to provide the capability of MALDI MS to analyze volatile compounds. Moreover, Co-NC is available for both positive and negative ionization modes without background interferences in the low-mass region (<500 Da) in MALDI MS, which tremendously extends the application of MALDI MS. Traditional matrix does not allow matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) to analyze volatile compounds, because volatile analytes may vaporize during the sample preparation process or in the high vacuum circumstance of ion source. Herein, we reported a Co and N doped porous carbon material (Co-NC) which were synthesized by pyrolysis of a Schiff base coordination compound. Co-NC could simultaneously act as adsorbent of volatile compounds and as matrix of MALDI MS, to provide the capability of MALDI MS to analyze volatile compounds. As adsorbent, Co-NC could strongly adsorb and enrich the volatile compounds in perfume and herbs, and hold them even in the high vacuum circumstance. On the other hand, Co-NC could absorb the energy of the laser, and then transfer the energy to the analyte for desorption and ionization of analyte in both negative and positive ionization modes. Additionally, the background interferences were avoided in the low-mass region (< 500 Da) when using Co-NC as matrix, overcoming the challenges of MALDI MS analysis of small molecule compounds. In summary, Co-NC as matrix tremendously extended the application of MALDI MS.